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Genotypic and Phenotypic Correlation Analysis of Primary Congenital Glaucoma and Its Impact on Surgical Outcomes

Genotypic and Phenotypic Correlation Analysis of Primary Congenital Glaucoma and Its Impact on Surgical Outcomes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500109224
Enrollment
Unknown
Registered
2025-09-15
Start date
2025-09-15
Completion date
Unknown
Last updated
2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary congenital glaucoma

Interventions

Observation group:None

Sponsors

The Zhongshan Ophthalmic Center,Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Simple angle developmental anomalies; 2. Age of onset 21 mmHg; (2) Optic disc cupping (disc margin narrowing): the cup-to-disc ratio progressively increases (generalized disc margin narrowing), asymmetric cup-to-disc ratios between both eyes (difference >= 0.2), or localized narrowing of the disc margin; (3) Corneal changes: presence of Haab's striae, corneal edema, or corneal diameter >= 11 mm (newborns), > 12 mm (children 13 mm (any age); (4) Progressive myopia or myopic shift combined with a rate of axial elongation greater than normal growth rate; (5) Corresponding to glaucomatous optic neuropathy, repeatable detectable visual field loss and excluding other conditions causing visual field loss.

Exclusion criteria

Exclusion criteria: 1.History of intraocular surgery; 2.Patients associated with other ocular or systemic abnormalities, such as a history of trauma, congenital iris dysplasia, Peters anomaly, Axenfeld-Rieger syndrome, and Sturge-Weber syndrome.

Design outcomes

Primary

MeasureTime frame
Genotype;

Countries

China

Contacts

Public ContactYimin Zhong

The Zhongshan Ophthalmic Center,Sun Yat-sen University

zhongyimin@gzzoc.com+86 18922103297

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026