Chronic insomnia
Conditions
Interventions
Conventional treatment + anesthesia induction sleep balance group:Dexmedetomidine-Propofol Induced Sleep Regulation Therapy
Conventional treatment group:Conventional treatment
Sponsors
The First People's Hospital of Zunyi
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age above 18 years old, both males and females are eligible. 2.Meet the diagnostic criteria for insomnia disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). 3.Total score of the Pittsburgh Sleep Quality Index (PSQI) > 7. 4.Voluntarily participate in the treatment and have signed the clinical informed consent form.
Exclusion criteria
Exclusion criteria: 1.Allergy to dexmedetomidine or propofol; 2.Presence of cardiac conduction block, severe ventricular dysfunction, severe hepatic or renal insufficiency, or other serious somatic diseases; 3.Abnormal blood pressure, bradycardia, or poorly controlled diabetes mellitus; 4.Detection of sleep apnea through polysomnography (PSG) conducted prior to treatment; 5.History of head trauma; 6.History of epilepsy, psychiatric disorders, or abnormal electroencephalogram (EEG) findings; 7.Known history of alcohol abuse or substance misuse; 8.Pregnancy, lactation, or planned pregnancy; 9.Educational level below elementary school or inability to comprehend the content of the rating scales used before and after treatment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Structure of sleep;Quality of sleep; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep diary;Adverse reactions;Hyperarousal condition;Vital signs;Blood biomarkers;Clinical efficacy;Patients' experience scores regarding the induction process;Anxiety and depression score;Multi-omics testing; | — |
Countries
China
Contacts
Public ContactXiong LiuLin
The First People's Hospital of Zunyi
Outcome results
None listed