Disorders of consciousness
Conditions
Interventions
pDOC group:None
Sponsors
The second people's hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: pDOC group: (1) Obtained consent from the subject's guardian, joined the study and signed the informed consent form;(2) Patients with chronic disturbance of consciousness;(3) Patients with stable vital signs (stable breathing and hemodynamics), and neurological symptoms no longer progressed;(4) Patients aged 18-85 years;(5) No central stimulants; no sedatives or neuromuscular blockers;(6) No history of epilepsy or other serious neurological and systemic diseases;(7) No contraindications for fMRI examination. HC group: (1) Persons with personal behavioral capacity are willing to join the study and sign the informed consent form;(2) Persons without neurological or psychiatric disorders;(3) No organic or functional swallowing disorders;(4) There are no other diseases or dysfunction that may seriously affect the study results.
Exclusion criteria
Exclusion criteria: pDOC group: (1) the condition of the primary disease still has significant changes, which is life-threatening and unstable;(2) the history of the primary disease causing disturbance of consciousness exceeds 1 year;(3) there are contraindications for fMRI;(4) brain structure defect; complete loss of hearing function; oral structure defect and other conditions that seriously affect swallowing function. HC group: (1) those who refused to sign informed consent;(2) those who had various diseases or dysfunction that seriously affected the study results;(3) those who took sedative drugs and neuromuscular blockers before and after the study;(4) those who had contraindications for fMRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revisions(CRS-R) score ;Simple Swallow Assessment Result;Changes in activity and functional networks of brain areas of interest on fMRI; | — |
Countries
China
Contacts
Public ContactJingpu Zhao
The second people's hospital of Shenzhen
Outcome results
None listed