Postoperative pain
Conditions
Interventions
Group O (Experimental Group):Oliceridine(0.4mg/kg)+Dexmedetomidine(2ug/kg)
Group S (Control Group):Sufentanil(2ug/kg)+Dexmedetomidine(2ug/kg)
Sponsors
Hanzhong Central Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Parturients with full-term pregnancy (= 37 weeks) scheduled for elective cesarean section, with a singleton fetus. 2. Aged 20–40 years, with a body mass index (BMI) of 18.5–30 kg/m². 3. Classified as American Society of Anesthesiologists (ASA) Physical Status I–II. 4. Free from underlying diseases, including hypertension, diabetes mellitus, and heart disease. 5. Informed consent signed by the parturient herself or her immediate family member (on her behalf). 6. Voluntarily accepting patient-controlled intravenous analgesia (PCIA) after surgery.
Exclusion criteria
Exclusion criteria: 1. Local or systemic infection: Skin infection at the block site, systemic infectious diseases, or sepsis. 2. Coagulation disorders: Abnormal coagulation function, such as prolonged prothrombin time (PT) or activated partial thromboplastin time (APTT), platelet count < 100×10?/L, or other coagulation impairments. 3. Severe spinal or lumbar diseases: Conditions that affect puncture operation or increase the risk of nerve injury, such as spinal deformity, acute attack of lumbar disc herniation, spinal stenosis, and abnormal anatomical structure of the quadratus lumborum muscle. 4. Allergy to anesthetic drugs: Known allergy to local anesthetics (e.g., lidocaine, ropivacaine) or intravenous analgesics (e.g., sufentanil). 5. Pregnancy complicated with severe complications: Conditions requiring emergency cesarean section or affecting the anesthetic plan, such as severe preeclampsia and placental abruption. 6. Other contraindications: Cardiac insufficiency (without underlying heart disease but with perinatal cardiac dysfunction), severe hepatic or renal insufficiency, etc. 7. History of long-term use of opioids or sedatives. 8. Emergency cesarean section. 9. Cesarean section with vertical incision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores at different time after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total Presses of PCIA,Effective Presses of PCIA,Actual Drug Consumption of PCIA;Ramsay Sedation Scale;24-Hour Postoperative Serum Levels of IL-6, TNF-a, and CRP;Time to First Ambulation After Surgery,Time to Bowel Function Recovery After Surgery,Length of Hospital Stay;Colostrum Onset Time,24-Hour Breastfeeding Frequency,BSES,SF-36; | — |
Countries
China
Contacts
Public ContactHuang Heng
Hanzhong Central Hospital
Outcome results
None listed