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A Prospective Head-to-Head Comparison Trial of Plasma EBV DNA or P85 Antibody versus VCA-IgA/EBNA1-IgA and Strategy Optimization for Nasopharyngeal Carcinoma Screening in High-Incidence Regions

A Prospective Head-to-Head Comparison Trial of Plasma EBV DNA or P85 Antibody versus VCA-IgA/EBNA1-IgA and Strategy Optimization for Nasopharyngeal Carcinoma Screening in High-Incidence Regions

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500109196
Enrollment
Unknown
Registered
2025-09-15
Start date
2025-09-15
Completion date
Unknown
Last updated
2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasopharyngeal Carcinoma

Interventions

Nasopharyngeal carcinoma case group:None
Healthy Control Group:None

Sponsors

The Fifth Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Nasopharyngeal carcinoma case group 1. Over 18 years old; 2. Those who have been diagnosed with nasopharyngeal carcinoma but have not received any anti-tumor treatment; 3. Residents of South China who have resided in South China for at least one year before recruitment. Healthy control group 1. Over 18 years old; 2. No previous history of nasopharyngeal carcinoma; 3. Residents of South China who have resided in South China for at least one year before recruitment.

Exclusion criteria

Exclusion criteria: 1.Severe medical comorbidities, significant organ (heart, lung, liver, kidney) dysfunction, or psychiatric disorders. 2.Severe autoimmune diseases or immunodeficiency. 3.Previously diagnosed with nasopharyngeal carcinoma and had received antitumor treatment before sampling.

Design outcomes

Primary

MeasureTime frame
Early-stage sensitivity;Advanced-stage sensitivity;Specificity;

Secondary

MeasureTime frame
Area under curve of ROC curve;Overall sensitivity;Number needed to detect one case;Negative predictive value;Positive predictive value;

Countries

China

Contacts

Public ContactLiu Youping

The Fifth Affiliated Hospital of Sun Yat-sen University

liuyp78@mail.sysu.edu.cn+86 13751763276

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026