Prolonged disorders of consciousness
Conditions
Interventions
unresponsive wakefulness syndrome Group :NA
Minimally Conscious State Group:NA
Healthy Control Group:NA
Sponsors
The First Affiliated Hospital of Air Force Medical University, Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Patients: 1. Age 18 to 80 years; 2. State of consciousness disorder due to brain injury or stroke lasting more than 28 days; 3. Stable vital signs, with no acute complications (such as acute pneumonia); 4. Patients or family members voluntarily participate, able to cooperate with the research process and sign the informed consent form. Inclusion Criteria for Healthy Volunteers: 1. Age 18 to 80 years, gender matching chronic consciousness disorder patients; 2. Voluntarily participate, able to cooperate with the research process and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients: 1.History of epilepsy or family history of epilepsy; 2.Presence of conductive, ferromagnetic, or other magnetically susceptible metals in the head and neck, or presence of a cardiac pacemaker; 3.Severe complications, including heart failure or renal failure; 4.History of alcohol dependence, neurological diseases, and other complex psychiatric disorders; 5.Use of sedative drugs and drugs that may interfere with brain stimulation, such as baclofen or N-methyl-D-aspartate (NMDA) receptor antagonists, within one week before enrollment and during the trial; 6.The patient or their family members refuse to participate in the trial. Exclusion criteria for healthy volunteers: 1.History of epilepsy or family history of epilepsy; 2.Use of sedative drugs and drugs that may interfere with brain stimulation, such as baclofen or N-methyl-D-aspartate (NMDA) receptor antagonists, within one week before enrollment and during the trial; 3.The volunteer refuses to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortical Theta Reactivity;TMS-evoked potentials;Event-related spectral perturbation;Local mean field amplitude;Significant current density;Significant oscillation envelope; | — |
Secondary
| Measure | Time frame |
|---|---|
| Significant current scattering;Structural equation model;Coma Recovery Scale Revised Score; | — |
Countries
China
Contacts
Public ContactYuan Hua
The First Affiliated Hospital of Air Force Medical University, Chinese People's Liberation Army
Outcome results
None listed