Hip fracture
Conditions
Interventions
10-gram group:No intervention
Control Group 1 (regional cerebral oxygen saturation =55%) showed a decrease of less than 5% compared to baseline:No red blood cell transfusion
Control Group 2 (regional cerebral oxygen saturation =55%) showed a decrease of more than 5% compared to baseline:Red blood cell transfusion
Sponsors
The First Affiliated Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients who may require allogeneic red blood cell suspension transfusion during surgery and within 72 hours postoperatively, and whose hemoglobin (Hb) level is below 10 g/dL (if autologous blood reinfusion is used perioperatively, then whose Hb remains below 10 g/dL after the complete reinfusion of autologous blood), will be formally enrolled and randomized into the study. If a patient experiences acute blood loss necessitating transfusion consideration while undergoing autologous blood reinfusion, they will also be enrolled if their Hb level is below 10 g/dL after the autologous blood reinfusion at that time point. Eligible patients will be assigned to groups according to their randomization number. Patients will be allocated into three groups in a 1:1:1 ratio, using randomization to balance the treatment groups. (A permuted block randomization with variable block size, 1:1:1 ratio, stratified by gender and fracture site (femoral neck, intertrochanteric, or subtrochanteric fracture), will be performed centrally through a data management system.)
Exclusion criteria
Exclusion criteria: Patients with hematological diseases, impaired hemoglobin oxygen-carrying capacity (such as methemoglobinemia), acute coronary syndrome (ACS), cardiopulmonary insufficiency, renal insufficiency, and multiple tumors and/or tumor metastases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transfusion rate and transfusion volume;All-cause mortality rate within 60 days in patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU admission rate and ICU length of stay;?Postoperative hemoglobin recovery;Drain removal time;Surgical incision healing status;Incidence of major complications;Length of hospital stay and hospitalization costs; | — |
Countries
China
Contacts
Public Contacthuangchangshun
The First Affiliated Hospital of Ningbo University
Outcome results
None listed