Metabolic-associated fatty liver disease
Conditions
Interventions
Observation group:None
Sponsors
The First Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-80 years; 2. Normal population (HC, healthy controls): Individuals undergoing routine health checks, without liver and gastrointestinal diseases, without tumor diseases, with normal blood glucose and lipid levels; 3. Liver cancer (HCC, hepatocellular carcinoma) patients: Confirmed by ultrasound, CT, MRI, AFP, and pathological examination, all liver cancer patients are newly diagnosed, without coexisting tumors and have not undergone treatment (initially collect based on imaging diagnosis and remove later if not applicable); 4. Liver cirrhosis (LC) patients: Patients with chronic liver disease diagnosed by two imaging examinations, or with pathological biopsy, liver function tests indicating compensated cirrhosis; 5. Metabolic associated steatohepatitis (MASH) patients: Diagnosed with fatty liver by imaging or liver biopsy and elevated serum transaminases (AST or ALT); 6. Simple fatty liver patients: Diagnosed with fatty liver by imaging or liver biopsy, with normal serum transaminases (AST or ALT); 7. Benign liver tumor (BLT) patients: Including hepatic hemangiomas, focal nodular hyperplasia of the liver, and hepatic adenomas.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with tumors other than those in the liver; 2. Received any anticancer treatment before blood sample collection; 3. Pregnant or breastfeeding women; 4. Clinically diagnosed with acute or chronic gastrointestinal diseases; 5. Individuals infected with human immunodeficiency virus (HIV) or related to acquired immunodeficiency syndrome (AIDS) diseases; 6. Conditions deemed unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Ferritin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Iron;GSH/GSSG; | — |
Countries
China
Contacts
Public ContactJin Junfei
The First Affiliated Hospital of Guilin Medical University
Outcome results
None listed