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10-degree Reverse Trendelenburg Position Combined with Norepinephrine to Improve Surgical Field Clarity in Middle Ear Surgery: A Randomized Controlled Trial

10-degree Reverse Trendelenburg Position Combined with Norepinephrine to Improve Surgical Field Clarity in Middle Ear Surgery: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109137
Enrollment
Unknown
Registered
2025-09-12
Start date
2025-09-12
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ear surgeries include tympanoplasty, ear canal surgery, and mastoidectomy.

Interventions

Group C:Lying flat position, pump in the same dose of normal saline.
Group B:10° reverse Trendelenburg position
Pump in the same dose of normal saline
Group A:10° reverse Trendelenburg position
Pump in a small dose of norepinephrine at 0.01 to 0.04 µg/kg/min.

Sponsors

Shandong Second Provincial General Hospital, Shandong Provincial ENT Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 60 years; 2. American Society of Anesthesiologists (ASA) classification I–III; 3. Elective ear surgery scheduled with an operation time of 1 to 3 hours; 4. General anesthesia planned; 5. Signed informed consent obtained and cooperation in data collection ensured.

Exclusion criteria

Exclusion criteria: 1.The operation time is either less than 1 hour or more than 3 hours. 2. Preoperative uncontrolled hypertension (SBP>180mmHg) or arrhythmia; 3. History of cerebral infarction; (4) Poorly controlled hypertension and severe heart disease; 4. Poorly controlled hypertension and severe heart disease; 5. BMI >= 30 kg/m²; 6. History of chronic pain or opioid medication; 7. Any other factors preventing cooperation with the research, such as language comprehension disorders.

Design outcomes

Primary

MeasureTime frame
Quality score of the technical field.;

Secondary

MeasureTime frame
Postoperative adverse reactions included nausea, vomiting, and dizziness.;Record HR, MAP, and BIS ;Record vasoactive drug administration, including norepinephrine, urapidil, and esmolol, during the operation.;

Countries

China

Contacts

Public ContactLiu Yue

Shandong Second Provincial General Hospital, Shandong Provincial ENT Hospital

liuyue05312021@126.com+86 531 8308 6292

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026