Patient undergoing laparoscopic surgery under general anesthesia
Conditions
Interventions
Experimental Group one:Remimazolam: Induction with 0.1 mg/kg/min
Maintenance with 1–2 mg/kg/h.
Experimental Group two:Remimazolam: Induction with 0.2mg/kg/min
Control Group:Propofol: Induction 2.5 mg/kg
Maintenance 4–12 mg/kg/h.
Sponsors
Changzhou Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, regardless of gender; 2. Scheduled for elective laparoscopic surgery under general anesthesia; 3. ASA physical status 18 kg/m^2 and <30 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Emergency surgery; 2.Planned open laparotomy or intraoperative conversion to laparotomy; 3.Hypertensive patients with uncontrolled blood pressure despite antihypertensive medication (Systolic BP >=160 mmHg and/or Diastolic BP >=100 mmHg); 4.Laboratory abnormalities: Anemia (Hb =2.5 × ULN; TBIL >=1.5 × ULN); Renal dysfunction (Serum creatinine > upper limit of normal); 5.Acute angle-closure glaucoma, myasthenia gravis, or acute alcohol intoxication; 6.Shock (Systolic BP <=90 mmHg) or comatose patients; 7.History of benzodiazepine allergy or tolerance; 8.Pregnant or lactating women; 9.Procedures requiring cardiopulmonary bypass, hepatectomy, or liver transplantation; 10.Participation in other drug clinical trials within 3 months prior; 11.Patients deemed ineligible by investigator or who decline participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction dose (remimazolam/propofol) at loss of consciousness;Modified Observer's Assessment of Alertness/Sedation Scale;Mean arterial pressure,MAP;Stroke volume index, SVI;Systemic vascular resistance index, SVRI; | — |
Countries
China
Contacts
Public ContactLi QIudong
Changzhou Cancer Hospital
Outcome results
None listed