Infection caused by carbapenem-resistant Gram-negative bacteria
Conditions
Interventions
Polymyxin E methanesulfonate blood concentration observation group:None
Sponsors
Tongde Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Patients clinically diagnosed or highly suspected of CRGNB infection; 3. Intravenous use of colistin methanesulfonate (CMS) for at least 3 days; 4. Those who agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who fail to cooperate in undergoing blood collection and related tests within the specified time; 2.Cases with incomplete data; 3.Pregnant or lactating women; 4.Other situations that the researchers deem unsuitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-infection effective rate;14-day or 28-day mortality rate;The effective and safe blood concentration threshold of polymyxin E; | — |
Secondary
| Measure | Time frame |
|---|---|
| LOS(length of hospital stay);PK/PD;Antimicrobial drug management indicators;Microbial reaction;The gene polymorphism of polymyxin e-methanesulfonic acid;Security Index; | — |
Countries
China
Contacts
Public ContactYuexing Tu
Tongde Hospital of Zhejiang Province
Outcome results
None listed