Painless labor
Conditions
Interventions
Esketamine group:Esketamine 1mg/ml was added to the delivery analgesic pump, respectively
Sufentanil group:and Sufentanil 0.3ug/ml was added to the delivery analgesic pump, respectively
Sponsors
Chinese People's Liberation Army Northern Theater Command General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-40 years old, ASA grade I to II, BMI BMI=37 weeks, single fetus, cephalic primipara/menpara, the mother and her family agreed to labor analgesia and signed informed consent; 3. no contraindications to intraspinal anesthesia; 4. The obstetrician and midwife assessed regular uterine contractions and met the conditions for vaginal birth.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to the active ingredient esketamine or local anesthetics; 2. The maternal cannot cooperate with the spinal canal puncture or can not cooperate with the scores, the maternal does not agree and refuses to sign the informed consent; 3. those who withdrew from the experiment and those whose results were suspicious; 4. High blood pressure or preeclampsia during pregnancy; 5. Patients who have or have had a history of serious mental disorders; 6. There are contraindications for intraspinal block, such as coagulation dysfunction, puncture site infection or injury, uncorrected maternal hypovolemia or hypotension, increased intracranial pressure, severe spinal deformity, etc.;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score 30min after the first dose;Pain score 24h after administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep scores ; Depression scores;Systolic blood pressure, diastolic blood pressure, heart rate, blood oxygen saturation, body temperature;First time of getting out of bed, first time of exhalation, first time of defecation, length of hospital stay; | — |
Countries
China
Contacts
Public ContactLin Li
Chinese People's Liberation Army Northern Theater Command General Hospital
Outcome results
None listed