Severe acute renal failure
Conditions
Interventions
Sodium and potassium ion concentration group in blood and sweat:None
Monitoring of sodium and potassium ions in the sweat of bedside dialysis patients group:None
Sponsors
Civil Aviation General Hospital
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Modeling the correlation between sodium and potassium ion concentrations in blood and sweat using a healthy population: 1. Age range: Select healthy adults aged 20 to 85 years. 2. Health status: No acute or chronic diseases, including but not limited to cardiovascular diseases, endocrine diseases, kidney diseases, liver diseases, neurological diseases, etc., ensuring that the metabolism and regulation mechanisms of sodium and potassium ions are normal and that the concentrations in blood and sweat are not affected by underlying diseases. 3. Lifestyle habits: Regular lifestyle, without significant dietary or lifestyle changes in the recent three months before enrollment, such as long-term staying up late, excessive drinking, smoking, etc., ensuring that the sodium and potassium intake and metabolism of the study subjects are in a relatively stable state. 4. Exercise situation: No professional endurance training or high-intensity exercise within one month prior to enrollment, as these exercises may temporarily affect sweat secretion and the excretion of sodium and potassium ions, leading to changes in sweat sodium and potassium ion concentrations that could interfere with the research results. 5. Informed consent: Able to understand and voluntarily sign the informed consent form, willing to cooperate with researchers throughout the entire study process, including the collection of blood and sweat samples and related examinations. For monitoring sweat sodium and potassium ion concentrations in bedside dialysis patients: 1. Clinically diagnosed with severe acute renal failure requiring bedside dialysis treatment expected to last 24 hours or more; 2. Age range: Between 20 and 80 years; 3. No allergic reactions to study materials; 4. Complete medical history and clinical data; 5. Patients or their family members agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: For the correlation model of sodium and potassium ion concentrations in blood and sweat using a healthy population: 1. Recent illness history: Having experienced fever, infection, diarrhea, or other illnesses within the 2 weeks prior to enrollment, as these conditions may lead to electrolyte imbalance in the body and affect the concentrations of sodium and potassium ions in blood and sweat. 2. Skin issues: Having any skin diseases that may affect sweat secretion and collection, such as eczema, psoriasis, severe acne, etc., which may make sweat collection difficult or affect the components of sweat. 3. Medication use: Taking medications within the 2 weeks prior to enrollment that may affect sodium and potassium ion metabolism, such as diuretics, certain antihypertensives, glucocorticoids, etc., as these may interfere with the balance and excretion of sodium and potassium ions in the body. 4. Allergy history: Having allergies to the blood sampling, sweat collection equipment, or related testing reagents used in the study, which may cause allergic reactions during the study and affect the smooth progress and accuracy of the results.5. Pregnant or nursing women: The physiological condition of pregnant and nursing women is special, with significant changes in hormone levels that may affect the metabolism and distribution of sodium and potassium ions, making them unsuitable for inclusion in the study. For monitoring sweat sodium and potassium ions in patients undergoing bedside dialysis: 1. Skin diseases: Having severe skin diseases such as extensive eczema, psoriasis, burns, scalds, etc., may affect the normal secretion and collection of sweat, leading to inaccurate monitoring results and should be excluded. 2. Endocrine diseases: Having uncontrolled endocrine diseases such as hyperthyroidism or hypothyroidism, primary aldosteronism, etc., as these conditions may cause disturbances in sodium and potassium ion metabolism, interfering with the interpretation of sweat sodium and potassium ion monitoring results. 3. Recent use of medications affecting sweat secretion: Using medications within the 2 weeks prior to enrollment that may affect sweat secretion, such as anticholinergic drugs, certain antihypertensives, etc., as these medications may change the amount and composition of sweat secretion, thereby affecting monitoring results. 4. Mental illness or cognitive impairment: Having severe mental illnesses or cognitive impairment that prevents cooperation with researchers for sweat collection and related examinations or understanding the requirements and precautions of the study. 5. Pregnant or nursing women; 6. Having a clear cause of secondary acute kidney failure, such as drug poisoning, trauma, etc.; 7. The patient or their family members do not agree to participate in the study or withdraw from the study midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sodium ions in the blood;Potassium ion concentration in the blood;Sodium ions in sweat;Concentration of potassium ions in sweat; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gender;Age;BMI;Comorbidity; | — |
Countries
China
Contacts
Public ContactYi Hu
Civil Aviation General Hospital
Outcome results
None listed