Early gastric cancer
Conditions
Interventions
Control group:Standard Helicobacter pylori eradication therapy is administered after ESD.
Preoperative Eradication Group:Standard Helicobacter pylori eradication therapy is administered prior to ESD.
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University, Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 75 years, no gender restrictions; 2. Endoscopically/biopsy-confirmed early gastric cancer lesions; 3. Meets absolute or expanded ESD indications according to the Japanese Society of Gastrointestinal Endoscopy Guidelines (2nd Edition); 4. Positive result in at least one of the following tests: ¹³C-urea breath test, Hp fecal antigen test, or rapid urease test; 5. Voluntarily participates in this study and signs the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of Hp eradication therapy within the past 3 months prior to recruitment; 2. History of gastric surgery; 3. Drug allergy or intolerance to Hp eradication therapy; 4. Pregnancy or lactation; 5. Contraindications for ESD-related procedures; 6. Preoperative use of anticoagulants other than aspirin, including warfarin, direct oral anticoagulants, P2Y12 receptor antagonists, or phosphodiesterase-3 inhibitors; 7. Participation in other clinical trials within the past 3 months or ongoing participation in other trials; 8. Other conditions deemed unsuitable for study participation at the investigator's discretion;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraoperative bleeding; | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative perforation;lesion detection rate;delayed postoperative bleeding;operative time;postoperative hospital stay;treatment cost; | — |
Countries
China
Contacts
Public ContactWei Zhang
Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University, Medical School
Outcome results
None listed