Gastrointestinal polyps, etc.
Conditions
Interventions
The 0.3 mg/kg cefoperazone + oxycodone group (Group C1):0.3 mg/kg cefoperazone + oxycodone
the 0.25 mg/kg cefoperazone + oxycodone group (Group C2):0.25 mg/kg cefoperazone + oxycodone
the 0.2 mg/kg cefoperazone + oxycodone group (Group C3):0.2 mg/kg cefoperazone + oxycodone
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing painless gastroscopy are aged 65 years or older, with no gender restrictions; 2. Both patients and their families have given informed consent; 3. American Society of Anesthesiologists (ASA) classification is grade I-III; 4. Patients without a history of long-term use of sedatives, analgesics, and antidepressants; 5. Conscious, able to communicate, without cognitive impairment or concurrent severe mental and neurological disorders.
Exclusion criteria
Exclusion criteria: 1. Including severe cardiovascular diseases, such as unstable angina pectoris, acute myocardial infarction, heart failure or arrhythmia within one month; 2. Have severe respiratory diseases, such as chronic bronchitis, asthma, COPD, emphysema, etc., or have had upper respiratory tract infection within one month prior to the surgery; 3. Complicated with severe cerebrovascular diseases, such as cerebral infarction, cerebral hemorrhage, severe stenosis of cerebral vessels, and intracranial aneurysms; 4. Abnormal liver and kidney functions, with AST and/or ALT >= 2.5×ULN, TBIL >= 1.5×ULN, urea or urea nitrogen >= 1.5×ULN, and serum creatinine higher than the upper limit of normal range; 5. Merge patients with severe mental disorders such as epilepsy and depression; 6. Patients with a history of long-term use of sedative, analgesic and antidepressant drugs; 7. Patients with preoperative cognitive impairment who are unable to communicate and cooperate with the diagnosis and treatment; 8. Patients with a history of allergies to anesthetics such as propofol and oxycodone; 9. Patients who are judged to have difficulty in managing their respiratory system, such as those with a modified Mallory score of level IV, or those with obstructive sleep apnea syndrome, or those with a body mass index (BMI) of >= 30 kg/m^2; 10. Hypertensive patients whose blood pressure has not been satisfactorily controlled (systolic blood pressure >=160 mmHg and/or diastolic blood pressure >=100 mmHg during the screening period).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of respiratory depression in each of the three groups of patients during the peri-general anesthesia gastroscopy period;; | — |
Secondary
| Measure | Time frame |
|---|---|
| SPO2, SBP, DBP, MAP, HR, RR and their change rates before and after endoscopy.;Other indicators: Occurrence of adverse reactions such as injection pain, coughing, body movement, hypertension and hypotension during the period of general anesthesia and intubation.;Compare the induction times, The time for a gastroscopy,endoscopy examination times, recovery times, and PACU stay times for each group.;Patient satisfaction after diagnosis and treatment;Usage of vasoactive drugs during endoscopic examination period;Total additional amount and frequency of ciprofol during induction of general anesthesia; | — |
Countries
China
Contacts
Public ContactMinhui Kan
Xuanwu Hospital Capital Medical University
Outcome results
None listed