White Matter Injury in Congenital Heart Disease
Conditions
Interventions
Cardiopulmonary bypass(CBP ):NA
DeepHypothermic Circulatory Arrest(DHCA):NA
Sponsors
Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Neonates to 18 years old; 2.Voluntary signing of informed consent; 3. CHD diagnosed by ultrasound.
Exclusion criteria
Exclusion criteria: 1.Presence of other severe neurological disorders, such as traumatic brain injury, brain tumors, intracranial infections, epilepsy, cerebral infarction, cerebral hemorrhage, metabolic encephalopathy, or non-vascular white matter lesions; 2. Use of medications affecting cognitive function within 24 hours; 3.Severe systemic diseases or major organ dysfunction; 4.Contraindications to MRI examination, such as the presence of a cardiac pacemaker, rendering completion of cranial MRI impossible; 5. Comorbid psychological disorders (e.g., depression) preventing neuropsychological scale assessment or a history of mental illness; 6. Dementia, long-term use of medications affecting cognitive function, or other conditions causing cognitive impairment; 7. Known genetic abnormalities; 8. Clinically identified congenital infections; 9.Patients unwilling to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| White matter injury; | — |
Countries
China
Contacts
Public ContactZhu Zhongqun
Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed