Mitral Valve Regurgitation
Conditions
Interventions
Moderate to severe and severe DMR Group:None
None/trivial or mild DMR Group:None
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Fully meeting the following criteria: (1) Age >= 18 years; (2) Outpatients or inpatients who visited Sun Yat-sen Memorial Hospital of Sun Yat-sen University between January 1, 2018, and September 30, 2024; (3) Completion of transthoracic echocardiography (TTE)/transesophageal echocardiography (TEE) during this period, with a confirmed diagnosis of moderate-to-severe or severe DMR based on comprehensive assessment of qualitative and quantitative echocardiographic indicators according to the Clinical Pathway for Transcatheter Mitral Valve Edge-to-Edge Repair in China (2022 Simplified Version) 11 (Figure 1); (4) Completion of routine electrocardiogram and ambulatory electrocardiogram during this period.
Exclusion criteria
Exclusion criteria: Meet any of the following criteria: (1) MR caused by other reasons; (2) Currently taking beta-blockers or any antiarrhythmic drugs; (3) Persistent atrial fibrillation; (4) Sick sinus syndrome; (5) Ventricular pacing proportion exceeding 10% after pacemaker implantation; (6) Combined moderate or higher aortic valve lesions; (7) Abnormal intracardiac shunt (e.g., atrial septal defect, ventricular septal defect, etc.); (8) MR caused by active infective endocarditis, acute myocardial infarction, etc., with duration less than 3 months; (9) Uncontrolled acute left heart failure; (10) Severe cardiac dysfunction (NYHA Class IV or LVEF <20%), or end-stage heart failure (ACC/AHA Stage D); (11) Untreated severe coronary artery stenosis; (12) Severe medical conditions such as severe infection, sepsis, acute exacerbation of COPD, severe hepatic or renal insufficiency, etc.; (13) Advanced cancer, rheumatic immune tissue diseases, severe infections, etc., or expected survival <1 year; (14) Pregnant or lactating patients; (15) Other reasons deemed by the investigator as unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ECG;Imaging;Various Ventricular Arrhythmias;Clinical;Biochemistry; | — |
Countries
China
Contacts
Public ContactMaohuan Lin
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed