Knee Osteoarthritis
Conditions
Interventions
BL:Bupivacaine Liposome
B:Bupivacaine Hydrochloride
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing primary unilateral total knee arthroplasty (TKA) under spinal anesthesia due to knee osteoarthritis (2) Age ranging from 18 to 75 years old (3) ASA classification ranging from grade I to grade III (4) Body mass index (BMI) ranging from 18 to 40 kg/m^2.
Exclusion criteria
Exclusion criteria: (1) History of surgery or infection at the puncture site (2) Allergy to the drugs used in the study (3) Coagulopathy (4) Pregnant or lactating women (5) Individuals with mental illness or speech disorders who cannot cooperate (6) Addiction to opioids (7) Having participated in other clinical trials within the past 3 months (8) Refusal to sign the informed consent form (9) Other conditions unsuitable to participate in the clinical trial, determined by the researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total consumption of sufentanil 0-72h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first press on the PCIA device as remedial analgesia;Area under the curve of pain score at rest during 0-72 hours postoperatively (AUC NRS-R 0-72);Area under the curve of pain scores on activity during 0-72 hours (AUC NRS-A0-72) postoperatively;NRS scores at rest and on activity at different time points during the 72-hour postoperative period;NRS score on activity on postoperative day 14;NRS scores on activity at postsurgical 3 months; | — |
Countries
China
Contacts
Public ContactAilin Luo
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed