Pain
Conditions
Interventions
Dex group:Prior to the cesarean section, dexmedetomidine at a dose of 0.5 µg/kg was administered via preemptive intranasal instillation.
Blank group:Prior to a cesarean section, the same volume of saline (dexmedetomidine 0.5ug/kg) was pre-nasal dropped.
Sponsors
Maternal and Child Health Hospital of Hubei Province
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Parturients undergoing cesarean section under spinal anesthesia; 2.18~45 years old; 3.ASAII; 4.Full-term pregnancy; 5.18.5=10; 8.Puerpera could communicate well with the follow-up, understand the trial process, voluntarily participate in the study and sign the relevant informed consent.
Exclusion criteria
Exclusion criteria: 1.Allergy to a2-agonists; 2.Preoperative placenta previa, placental abruption and other diseases with estimated blood loss greater than 800 ml; 3.Preoperative sinus bradycardia (maternal heart rate less than 50 beats/min), or cardiac conduction or sick sinus syndrome abnormal cardiac rhythm diseases; 4.Preoperative hypotension (defined as systolic blood pressure < 90mmHg and/or diastolic blood pressure < 60mmHg); 5.Patients with unstable mental disorders or depressive disorders; 6.History of psychotropic drugs and alcohol abuse; 7.Long-term use of a drug within 6 months before the study; 8.Participating in other clinical drug trials during the same period; 9.Unable to understand the language of the follow-up, unable to communicate well; 10.Cases deemed unsuitable for collection by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual pain score;Apgar score;Edinburgh Postnatal Depression Scale (EPDS) Score;Heart rate;Blood presure;Oxygen saturation;Perioperative adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of satisfaction;The volume of blood loss during childbirth; | — |
Countries
China
Contacts
Public ContactWei Yan
Hubei Maternal and Child Health Hospital
Outcome results
None listed