Schizophrenia
Conditions
Interventions
Adaptive N-back Working Memory Training Group:Adaptive N-back Working Memory Training
Non-adaptive 1-back Control Group:Non-adaptive 1-back Training
Treatment-as-Usual Group:Treatment as Usual
Sponsors
Northwest Normal University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 65 years; (2) Diagnosis of schizophrenia established by two resident psychiatrists according to the International Classification of Diseases, 10th Revision (ICD-10) criteria (F20.9), and further confirmed with the Structured Clinical Interview for DSM (SCID); (3) Clinically stable, defined as receiving the same type of antipsychotic medication at a maintenance dose for at least six consecutive weeks, with less than a 20% change in total Positive and Negative Syndrome Scale (PANSS) score; (4) Sufficient cognitive and communicative ability to complete experimental tasks and voluntarily provide written informed consent.
Exclusion criteria
Exclusion criteria: (1) Presence of severe physical illnesses, such as major cardiovascular or cerebrovascular diseases, epilepsy, or malignant tumors; (2) Corrected visual acuity below 0.8; (3) Long-term use of medications known to impair cognitive function (e.g., benzodiazepines, antihistamines, anticholinergics, sedatives) or a history of alcohol abuse; (4) Antipsychotic medication dosage exceeding the olanzapine-equivalent of 35 mg/day; (5) Prominent extrapyramidal symptoms or other severe adverse drug reactions that may interfere with the performance of behavioral tasks; (6) History of organic brain injury, such as traumatic brain injury or cerebrovascular disease; (7) Substance abuse within six months prior to enrollment; (8) Participation in other clinical studies within three months prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Executive Function Composite Assessment;PANSS Clinical Scale; | — |
Countries
China
Contacts
Public ContactXin Zhao
Northwest Normal University
Outcome results
None listed