Comparison of Hemodynamic Parameters and Postoperative Quality of Recovery Between Remimazolam and Propofol in Elderly Patients Undergoing Gastrointestinal Endoscopic Mucosal Resection (EMR)

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500109016

Enrollment

Unknown

Registered

2025-09-10

Start date

2025-09-15

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Painless Gastrointestinal Endoscopic Mucosal Resection (EMR) in Elderly Patients

Interventions

Remimazolam:Remimazolam

Propofol:Propofol

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age between 65 and 80 years, planned for gastrointestinal EMR (Boston score >= 6 points); 2. ASA classification II-III, baseline MMSE >= 24 points (illiterate >= 17 points); 3. Body mass index (BMI) 18-28 kg/m^2; 4. Voluntarily signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Allergy to benzodiazepines or propofol; 2. Severe liver and kidney dysfunction (Child-Pugh Class C or eGFR <30 mL/min/1.73m^2); 3. Severe cardiovascular disease (NYHA Class III-IV heart failure, unstable angina); 4. Difficult airway or high ventilation risk; 5. Long-term use of sedatives or opioids; 6. Cognitive dysfunction (MMSE <24 points); 7. Emergency surgery.

Design outcomes

Primary

Measure	Time frame
Incidence of hypotension;Delirium;Postoperative Quality of Recovery;	—

Secondary

Measure	Time frame
The vital signs of the patient;Incidence of hypoxemia;Emergence time ;	—

Countries

China

Contacts

Public ContactMin Yu

Jiangsu Provincial People's Hospital

myu@njmu.edu.cn+86 136 7518 5692

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026