Alcohol Use Disorder
Conditions
Interventions
? Oscillation TIs-Insula Group:Temporal Interference Stimulation
Sham Stimulation Group (without TIs):Sham Stimulation
Healthy Control Group:none
Patients With AUD:none
Sponsors
Beijing HuiLongGuan Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Meeting the clinical diagnostic criteria for moderate to severe Alcohol Use Disorder (AUD) as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), i.e., fulfilling four or more diagnostic criteria specified in the manual; 2.Aged 18–65 years with an educational background of >=6 years of formal schooling; 3.Having completed acute detoxification treatment with no obvious withdrawal symptoms, and a score of =5 standard drinks per day for males and >=4 standard drinks per day for females; 8.Voluntarily participating in the study and signing the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Meeting diagnostic criteria for other mental disorders as defined by the DSM-5, such as bipolar disorder, schizophrenia, or intellectual disability; 2.Having residual alcohol-related psychotic symptoms for less than one week, or having discontinued antipsychotic medications for such symptoms for less than one week; 3.Having a clear history of epileptic seizures or delirium tremens; 4.Currently receiving other alcohol abstinence treatments, including systematic psychotherapy, or having undergone physical regulatory treatments such as transcranial alternating current stimulation (tACS), transcranial magnetic stimulation (TMS), or modified electroconvulsive therapy within the past 6 months; 5.Comorbid with dependence on other psychoactive substances (excluding tobacco); 6.Suffering from any severe or uncontrollable systemic diseases (e.g., diseases of the respiratory, circulatory, digestive, nervous, hematological, genitourinary, or endocrine systems); 7.Having taken immunosuppressants (including immune inhibitors), hormones, antioxidants, neurotrophic drugs, traditional Chinese medicine preparations, or having had an infectious disease within 12 weeks prior to enrollment; 8.Concomitantly taking other alcohol abstinence-related medications, such as naltrexone or acamprosate; 9.Being pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drinking capacity;Alcohol-Related Consequences Score : Self-rated scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of Alcohol Dependence: Self-rated scale;Emotional State: Self-rated scale;Impulsiveness and inhibition ability;Alcohol craving level: Self-rated scale;Impulsivity Level: Self-rated scale;Reward Expectation and Outcome Level;Sustained Attention Ability;Imaging indicators; | — |
Countries
China
Contacts
Public ContactHu Deng
Beijing HuiLongGuan Hospital
Outcome results
None listed