Post-stroke Aphasia
Conditions
Interventions
Sham groups:The sham group will receive the same procedures using a sham coil, with identical speech therapy sessions.
Individualized target groups:Participants will receive individualized intermittent theta burst stimulation (iTBS) based on the integrity of the left frontal aslant tract (FAT), de
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Course of post-stroke aphasia between 1 to 3 months. 2.First-ever ischemic stroke confirmed by cranial CT or MRI, with a single lesion located in the left cerebral cortical hemisphere. 3.Single lesion and first stroke episode, with a course of 1 month; 4.Diagnosed with aphasia according to the Western Aphasia Battery (WAB); 5.Aged between 50 and 75 years (inclusive); 6.Native Chinese speakers with normal language function prior to stroke onset; 7.Education level of primary school or above; 8.Right-handed; 9.No history of language impairment prior to stroke; 10.Fully informed about the procedures of repetitive transcranial magnetic stimulation (rTMS) and neuroimaging scans involved in the study and have signed the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Presence of visual or auditory impairments that affect language assessment or treatment. 2.Impaired consciousness or inability to cooperate with assessments and interventions. 3.History of language impairment prior to the current stroke, or presence of severe dysarthria during this episode. 4.Coexisting neurodegenerative diseases causing speech impairment, such as dementia, Parkinson's disease, or motor neuron disease. 5.History of epilepsy, substance abuse, or psychiatric disorders. 6.Presence of metallic foreign bodies in the body or implanted electronic medical devices (e.g., pacemakers, cochlear implants).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western aphasia battery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Boston Naming Test (BNT);Resting-state functional magnetic resonance imaging;The Non-language-based Cognitive Assessment (NLCA); | — |
Countries
China
Contacts
Public ContactDaoran Wang
Wuxi Mental Health Center
Outcome results
None listed