Diabetes mellitus
Conditions
Interventions
Uncomplicated diabetes mellitus:NA
Prediabetes:NA
DM with renal complications:NA
DM with ophthalmic complications:NA
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Diabetes mellitus group: Diagnosed according to internationally recognized criteria (e.g., World Health Organization [WHO] or American Diabetes Association [ADA]), including type 1 and type 2 diabetes mellitus, further subdivided into diabetic retinopathy, diabetic nephropathy, and uncomplicated diabetes mellitus. 2.Prediabetes group: HbA1c levels meeting internationally recognized prediabetes criteria (WHO or ADA). 3.Healthy controls: Participants without diabetes mellitus or prediabetes and who do not meet any exclusion criteria. 4.Age >=18 years. 5.Written informed consent obtained.
Exclusion criteria
Exclusion criteria: 1.Severe systemic diseases, such as advanced renal failure (eGFR <30 mL/min/1.73 m^2), other significant renal diseases, hepatic or cardiac failure, respiratory or central nervous system disorders, and malignancies. 2.Psychiatric disorders or severe cognitive impairment. 3.Ocular conditions other than diabetic retinopathy. 4.Acute inflammation or infection. 5.History of neurotoxicity due to medications or metabolic neurotoxicity related to renal impairment. 6.Pregnancy or lactation. 7.Participation in other studies potentially affecting follow-up schedules. 8.Other conditions deemed inappropriate by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baseline target protein indicator value; | — |
Countries
China
Contacts
Public ContactBiao Yan
Shanghai General Hospital
Outcome results
None listed