Postoperative nausea and vomiting after laparoscopic cholecystectomy
Conditions
Interventions
Aprepitant Injection Group (Group T):Administer 32 mg of Aprepitant (i.e., 4.4 ml of Aprepitant mixed with 5.6 ml of 0.9% saline, totaling 10 ml) via intravenous push within one hour before anesthesia
Ondansetron hydrochloride group (Group C):Administer 4 mg of Ondansetron by intravenous push (i.e., 2 ml of Ondansetron diluted with 8 ml of 0.9% saline, totaling 10 ml) within 1 hour prior to anesthe
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 80 years; 2. Patients planning to undergo elective laparoscopic cholecystectomy; 3. Patients planning to receive total intravenous anesthesia; 4. American Society of Anesthesiologists (ASA) physical status classifications I to III; 5. Body Mass Index (BMI) between 18 and 28 kg/m^2;
Exclusion criteria
Exclusion criteria: 1. Patients who have taken known antiemetic drugs before surgery; 2. Patients who are pregnant or breastfeeding; 3. Patients allergic to any study medication; 4. Patients with a preoperative VAS score for nausea greater than 4 (out of 10); 5. Patients currently taking or planning to take drugs such as rifampicin, carbamazepine, phenytoin, or other strong CYP3A4 inducers; 6. Patients with moderate to severe liver dysfunction; 7. Patients with a history of neurological or psychiatric disorders; 8. Uncooperative patients; 9. Patients experiencing severe surgical complications perioperatively; 10. Patients who are difficult to communicate or cooperate with;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate (CR rate) within 24 hours post-operation with no vomiting and no rescue.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete response rate (CR rate) within48 hours post-operation with no vomiting and no rescue.;Severity of postoperative nausea and vomiting;Pain intensity (VAS);Quality of Recovery (QoR-15) two days after surgery; | — |
Countries
China
Contacts
Public ContactZhongyun Wang
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed