HPV-Related Cervical Diseases
Conditions
Interventions
Normal:Not Applicable
HPV Infection:Not Applicable
CIN I:Not Applicable
CIN II:Not Applicable
Cancer:Not Applicable
CIN III:None
Sponsors
Guangzhou Women and Children’s Medical Center Liuzhou Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Females aged 18 and above, who are not postmenopausal. 2. Patients infected with high-risk HPV types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68) undergo biopsy under colposcopy with a fully visible transformation zone. 3. Diagnosis of chronic cervicitis, CIN I, CIN II, CIN III, or cervical cancer is made based on biopsy pathology results. 4. No use of vaginal douches, antibiotics, or antifungal medications within 30 days prior to treatment. 5. No cervical physical therapy has been performed within the 3 months prior to treatment.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breastfeeding. 2. History of cervical excision, cervical neoplasia, or pelvic radiotherapy. 3. Concurrent acute inflammation of the reproductive system. 4. Concurrent severe impairment of heart, liver, or kidney function. 5. Concurrent diabetes or immune system diseases. 6. Coagulation function abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bioinformatics Analysis (Metabolic Pathway Analysis);Upstream Gene Validation in Metabolic Pathways; | — |
Countries
China
Contacts
Public ContactJing Chen
No. 50, Boyuan Avenue, Yufeng District, Liuzhou City, Guangxi and No. 50, Yingshan Street, Chengzhong District, Liuzhou City, Guangxi
Outcome results
None listed