Effect of Pretreatment with Low-Dose Oliceridine on Etomidate-Induced Myoclonus During Anesthesia Induction

Effect of Pretreatment with Low-Dose Oliceridine on Etomidate-Induced Myoclonus During Anesthesia Induction: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500108944

Enrollment

Unknown

Registered

2025-09-09

Start date

2025-09-15

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Etomidate-induced myoclonus

Interventions

Saline Group:An equal volume of normal saline was intravenously administered.

Oliceridine Group:Oliceridine (0.02 mg/kg IV) was administered.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-65 years old, ASA grade I-II 2.Body Mass Index 18-28 kg/m^2.

Exclusion criteria

Exclusion criteria: 1.Patients with adrenocortical dysfunction; 2.Patients with hepatic or renal insufficiency; 3.Presence of a difficult airway; 4.Possible allergy to drugs related to this study; 5.Patients with psychiatric or cognitive impairments; 6.Patients who received sedation/anesthesia within 24 hours prior to anesthesia induction.

Design outcomes

Primary

Measure	Time frame
Myoclonus incidence and severity;	—

Secondary

Measure	Time frame
Adverse reactions after premedication;Hemodynamic changes and BIS changes;Patient satisfaction;Time to loss of consciousness;	—

Countries

China

Contacts

Public ContactFanceng Ji

Weifang People's Hospital

jifanceng@163.com+86 135 6369 8838

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 8, 2026