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Effect of nalbuphine combined with remazolam on traction reaction during cesarean section under spinal anesthesia : a single-center randomized controlled trial

Effect of nalbuphine combined with remazolam on traction reaction during cesarean section under spina

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108913
Enrollment
Unknown
Registered
2025-09-09
Start date
2025-09-09
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section traction reaction

Interventions

Nalbuphine + remazolam :After fetal removal and umbilical cord clamping : nalbuphine 0.1 mg / kg After mother-infant combination : Remazolam 0.05 mg / kg and pumped into 0.1 mg / kg.h.
placebo :After fetal removal and umbilical cord clamping : normal saline 0.1 mL / kg After mother-infant combination : normal saline 0.05 mL / kg and pumping 0.1 mL / kg.h.

Sponsors

Kunming Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.ASA grade II-III 2.Age between 18 and 40 years old 3.Gestational age at 36 weeks and above and scheduled for selective routine cesarean section under spinal anesthesia.

Exclusion criteria

Exclusion criteria: 1 ,with spinal anesthesia contraindications 2, serious liver or kidney damage, heart and lung disease 3. There are uterine rupture, umbilical cord prolapse, pregnancy-induced hypertension, preeclampsia, eclampsia and other serious obstetric complications. 4, body mass index of 35 kg / m^2 and above 5 Intravertebral anesthesia block incomplete or failure, transfer to general anesthesia 6.Intraoperative bleeding more than 1500ml 7. Allergic or intolerant to any study drug

Design outcomes

Primary

MeasureTime frame
visceral traction reaction;

Secondary

MeasureTime frame
ramsay sedation score;patient satisfaction;

Countries

China

Contacts

Public ContactMeng Juan

Kunming Maternal and Child Health Hospital

2397119145@qq.com+86 159 8710 6371

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 20, 2026