Breast cancer
Conditions
Interventions
Early HR-positive premenopausal breast cancer patients observation group:None
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female breast cancer patients who have not yet reached menopause during surgery; 2. Newly diagnosed patients with invasive breast cancer at TNM stage I-III; 3. HR positive (defined as ER >= 10% and/or PR >= 10%); 4. Have undergone radical breast cancer surgery and plan to receive OFS treatment; 5. Have received (neo)adjuvant chemotherapy and radiotherapy; 6. ECOG PS 0-1; 7. Complete case records; 8. Willing to accept long-term follow-up; 9. Adverse events occurring during adjuvant chemotherapy (if any) have resolved or decreased to grade 1 (according to CTCAE v5.0) at the start of OFS treatment.
Exclusion criteria
Exclusion criteria: 1. Participating simultaneously in another blinded clinical trial; 2. Presence of other active malignant tumors or multiple primary cancers; 3. Pregnant or breastfeeding women; 4. Situations deemed inappropriate for inclusion in the study by the investigator; 5. Planning to use systemic treatment outside of the study protocol description during the endocrine therapy phase (e.g., but not limited to chemotherapy, ADC, or immunotherapy, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OFS discontinuation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival period of non-invasive diseases;Time to deterioration, TTD; | — |
Countries
China
Contacts
Public ContactYu Yang
Zhejiang Cancer Hospital
Outcome results
None listed