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Research on the Effect and Mechanism of Repetitive Transcranial Magnetic Stimulation in Alleviating Pain Hypersensitivity in Post-Stroke Patients with Shoulder-Hand Syndrome Complicated by Peripheral Nerve Sensitization

Research on the Effect and Mechanism of Repetitive Transcranial Magnetic Stimulation in Alleviating Pain Hypersensitivity in Post-Stroke Patients with Shoulder-Hand Syndrome Complicated by Peripheral Nerve Sensitization

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108900
Enrollment
Unknown
Registered
2025-09-08
Start date
2025-09-08
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke shoulder-hand syndrome patients

Interventions

Treatment group:Repetitive transcranial magnetic stimulation treatment added on the basis of conventional rehabilitation therapy
Sham-treatment group:underwent sham repetitive transcranial magnetic stimulation (rTMS) superimposed on conventional rehabilitation therapy
Control group:Conventional rehabilitation therapy

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Stroke patients with hemiplegia of one limb who meet the diagnostic criteria set by the 4th Cerebrovascular Disease Academic Conference of the Chinese Medical Association, confirmed by CT and/or MRI, and have the onset for the first time; 2. The stage of shoulder and hand syndrome is stage I.-II., and the diagnosis refers to the standards formulated by the China Rehabilitation Research Center; 3. Stable vital signs; 4. The affected limb is accompanied by hyperalgesia symptoms; 5. Under 80 years old; 6. No serious cardiovascular disease, liver and kidney insufficiency, malignant tumors and other critical diseases; 7. Voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Accompanied by arthritis, rheumatoid, fracture, injury and other diseases of the upper limbs such as shoulders and hands; 2. Upper limb pain caused by other diseases such as cervical spondylosis or myocardial infarction; 3. Lack of consciousness, cognitive dysfunction, etc. 4. Received local injection analgesia and other treatments for shoulder and hand syndrome within 4 weeks; 5. Use of hormones, painkillers, stimulants and sedatives within 48 hours; 6. Contraindications to repetitive transcranial magnetic stimulation, such as pacemakers, intracranial electrical stimulators, dentures, etc.; 7. Previous history of chronic pain.

Design outcomes

Primary

MeasureTime frame
Mechanical pain threshold;ROM;Inflammatory cytokines;VAS;Nerve growth factor (NGF);Pain substance;

Countries

China

Contacts

Public ContactFeng Liang

Zhejiang Provincial People's Hospital

fenglcm168@163.com+86 137 5716 8389

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026