decompensated cirrhosis
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of decompensated cirrhosis. 2. Age: 18–75 years. 3. Undergoing or planning to receive etiology-targeted treatment for liver cirrhosis (e.g., antiviral therapy, alcohol abstinence). 4. Child-Pugh class B or C, or Model for End-Stage Liver Disease (MELD) score between 10 and 30. 5. Voluntarily participates in the study, signs the informed consent form, strictly adheres to the intervention protocol, and attends follow-up visits as required to provide samples and clinical data.
Exclusion criteria
Exclusion criteria: 1. Presence of severe contraindications to fecal microbiota transplantation (FMT), such as sepsis, severe intestinal barrier compromise (e.g., active massive gastrointestinal bleeding, perforation), fulminant colitis, or immunodeficiency. 2. Concurrent severe comorbidities including type 1 diabetes mellitus, major cardiovascular/cerebrovascular diseases, hepatic/renal insufficiency, malignancy, psychiatric disorders, or autoimmune diseases. 3. Pregnancy or lactation. 4. Expected survival < 6 months. 5. Use of immunosuppressants, probiotics, or other agents affecting gut microbiota within the past two weeks. 6. Other exclusion criteria: known allergy to FMT, inability to comply with study procedures, or investigator-determined unsuitability for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MELD score;Child-Pugh classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota;SCFA;Cytokines (IL-1 ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, TNF - a, INF - a, INF - ?);Liver Fibroscan;Quality of life scale;PLT; | — |
Countries
China
Contacts
Public ContactGao Yueqiu
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed