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A randomized controlled study on the efficacy and safety of fractional picosecond laser and microplasma fractional radiofrequency in the treatment of acne scars and a preliminary exploration of their repair mechanisms.

A randomized controlled study on the efficacy and safety of fractional picosecond laser and microplasma fractional radiofrequency in the treatment of acne scars and a preliminary exploration of their repair mechanisms.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108892
Enrollment
Unknown
Registered
2025-09-08
Start date
2025-09-08
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne scars

Interventions

Fractional picosecond laser side:1064nm fractional picosecond laser treatment
Fractional radiofrequency side:Microplasma fractional radiofrequency treatment

Sponsors

Beijing Jishuitan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years old with atrophic acne scars and facial symmetry, who are able to understand and voluntarily sign a written informed consent form, and can complete treatment and follow-up as required.

Exclusion criteria

Exclusion criteria: 1. History of keloid disease; 2. History of oral retinoic acid, facial injections and fillers, chemical peeling, microneedling, dermabrasion and other energy device treatments for acne scars within 6 months prior to and during treatment; 3. History of photosensitivity and currently taking photosensitive medications; 4. History of allergy to lidocaine; 5. Coagulation dysfunction; 6. Impaired immune function (HIV positive or those who have taken oral corticosteroids or immunosuppressants within 3 months prior to treatment); 7. Patients with malignant tumors on the face; 8. Pregnant and breastfeeding women; 9. Active acne, specific dermatitis or bacterial/viral infections on the face; 10. Patients with mental illness.

Design outcomes

Primary

MeasureTime frame
The change in the ECCA grading scale at the last follow-up visit;

Secondary

MeasureTime frame
The Investigator’s Global Assessment (IGA) scores at the last follow-up visit;The change in the Goodman-Baron scores at the last follow-up visit;Patient-assessed acne scars improvement grade scores at the last follow-up visit;Patient satisfaction to the improvement of acne scars, pores and textures at the last follow-up visit.;

Countries

China

Contacts

Public ContactLi Jing

Beijing Jishuitan Hospital, Capital Medical University

sophiali79@126.com+86 10 5851 6324

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026