Pruritus
Conditions
Interventions
Group N:Half an hour before the end of the operation, 4 mg of nalbuphine was given intravenously (diluted to 10 ml with normal saline). The postoperative intravenous PCA analgesia pump formula was hyd
Group C:10 ml of normal saline was given intravenously half an hour before the end of the surgery, and the postoperative intravenous PCA analgesia pump was formulated with hydromorphone.
Sponsors
The First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria (patients must meet the following criteria to be eligible): 1. Aged 18 or older and able to give informed consent (with explanations provided if necessary) 2. Undergoing one or more of the following types of elective laparoscopic or robotic-assisted laparoscopic abdominal surgery: Colorectal surgery Gynecological surgery Urological/renal surgery 3. Estimated operative time = 2 hours (from skin incision to wound closure) 4. Estimated hospital stay = 24 hours (starting at midnight on the day of surgery)
Exclusion criteria
Exclusion criteria: Exclusion Criteria (patients were excluded if any of the following were met): 1. Allergy to study drug; 2. Inability to perform intrathecal injection due to anatomical reasons; 3. Anticipated invasive mechanical ventilation after surgery; 4. American Society of Anesthesiologists (ASA) class IV or higher; 5. Coagulopathy (i.e., INR > 1.3 and/or platelet count < 100 × 10^9/L); 6. Cognitive or language impairment, unable to participate in the study and complete questionnaires; 7. Failure to appropriately and promptly discontinue medications that affect coagulation (except aspirin) before surgery; 8. Infection near the site of anticipated intrathecal injection; 9. Ongoing sepsis; 10. Patients already enrolled in the trial whose postoperative condition necessitates return to the operating room for a new abdominal surgery; 11. Pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Itching score; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score;pain NRS score;Respiratory depression;Nausea and vomiting score; | — |
Countries
China
Contacts
Public ContactFeng Xia
The First Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed