Patients with cognitive disorders
Conditions
Interventions
Healthy Control group (study 1,Can be shared with Study 1):None
Healthy Control group (study 2):None
Mild Cognitive Impairment patient group (study 2):None
Mild Cognitive Impairment patient group (study 3):Non-invasive brain stimulation (NIBS)
Sponsors
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-80 years old 2.Gender: No specific restrictions, but the study aims to balance gender (e.g., approximately 50% male and 50% female) to control for gender bias. 3.Study 1: No cognitive impairment (MoCA score >= 26) 4.Studies 2 & 3: Presence of cognitive impairment (MoCA score < 26, including but not limited to Alzheimer's disease, mild cognitive impairment, vascular cognitive impairment, traumatic brain injury, etc.)
Exclusion criteria
Exclusion criteria: 1.Presence of severe visual, hearing, or speech impairments that prevent effective communication, inability to cooperate, or refusal to participate. 2.Unstable medical conditions, such as severe pulmonary or cardiac diseases, history of liver or kidney failure or malignant tumors, or presence of proximal deep vein thrombosis in the lower limbs. 3.History of psychiatric or psychological disorders: e.g., schizophrenia, bipolar disorder, depression, etc. 4.Long-term use of medications that may affect neurological or cognitive function (applies to healthy participants). 5.History of major surgery or hospitalization within the past 6 months (applies to healthy participants). 6.Significant psychological stress triggered by major life events (e.g., bereavement, unemployment) within the past 3 months. 7.Participation in other clinical trials or interventional studies that may interfere with the results within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Task-related HbO2 concentration changes (changes in cerebral blood flow).;Resting-state functional connectivity strength.;Heart rate variability;Montreal Cognitive Assessment (MoCA);Cognitive Load;Arousal; | — |
Countries
China
Contacts
Public ContactLin Feng
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University
Outcome results
None listed