diabetic macular edema
Conditions
Interventions
Anatomical improvement sensitive group (?CRT > 50 µm), anatomical improvement insensitive group (?CRT <=50 µm):None
Sponsors
Shanghai Sixth People's Hospita
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age >=18 years old; Confirmed DME (OCT confirmed: macular central retinal thickness (CRT) measured by OCT >=250µm); Complete three basic injections +PRN anti-VEGF treatment; Complete baseline and follow-up OCTA data are available.
Exclusion criteria
Exclusion criteria: 1. Combined with other eye diseases such as retinal vein occlusion, age-related macular degeneration, macular hole, uveitis, glaucoma, etc. 2. Those who have undergone cataract surgery within the past two months; 3. Those who have a history of vitrectomy or other ophthalmic surgeries; 4. Those who have been treated with other treatment regimens for DME, such as intravitreal or retrobulbar injection of glucocorticoids. 5. Uncontrolled hypertension or poor blood sugar control with glycated hemoglobin > 12%; 6. A cerebrovascular accident or myocardial infarction has occurred within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the thickness of the macular fovea retina; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in best corrected visual acuity;The mean blood flow density (VD) of the superficial retinal capillary cluster (SCP) and the deep retinal capillary cluster (DCP);Retinal outer layer blood flow density (ORVD) in the macular area;Choroidal capillary layer blood flow density ;Retinal capillary non-perfusion area (RNPA);Choroidal vascular index (CVI);Parameters of the foveal avascular zone (FAZ);Thickness variation of GCC;Hyperreflective foci within the retina;Disorder of the inner layer structure of the retina;Ellipsoid zone - continuity of the outer membrane;Perioptic disc blood flow index (PFI);Thickness of the retinal nerve fiber layer around the optic disc;The number of neovascularization in the optic disc; | — |
Countries
China
Contacts
Public ContactJin Yanling
Shanghai Sixth People's Hospita
Outcome results
None listed