stroke
Conditions
Interventions
fNIRS-rTMS Group:90% RMT applied on the ipsilesional fNIRS-guided hotspot (fNIRS-HS)
Conventional rTMS Group:90% RMT applied on the ipsilesional M1
Sham Stimulation Group:rTMS applied with conventional anatomical positioning with stimulation intensity set to zero
Healthy Control Group:none
Sponsors
The Eighth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Healthy Participants: (1) Age between 18 and 80 years; (2) In good general health; (3) Conscious, cognitively intact, emotionally stable, and able to follow instructions to complete the experiment; (4) Voluntarily provide written informed consent. Inclusion Criteria for Stroke Patients: (1) Diagnosis of stroke confirmed by MRI or CT imaging; (2) Age between 18 and 80 years; (3) Presence of upper limb motor dysfunction (score >1 on item 5 of the National Institutes of Health Stroke Scale, NIHSS); (4) Mini-Mental State Examination (MMSE) score >24; (5) Voluntarily provide written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for healthy subjects: (1) Any neurological or mental illness; (2) Severe heart, lung, kidney, or other organ diseases; (3) Contraindications to rTMS, such as a history of epilepsy, a pacemaker or implantable cardioverter-defibrillator, metal or magnetic objects in the brain, cochlear aneurysm clips or coils, metal plates in the head/brain, and drug pumps; (4) Cognitive impairment, visual or auditory impairment, and inability to cooperate with operating instructions; (5) Unable to tolerate fNIRS equipment for 30 minutes. Exclusion criteria for stroke patients: (1) Contraindications to rTMS, including a history of epilepsy, pacemaker or implantable cardioverter-defibrillator, intracranial metal or magnetic implants, cochlear implants, aneurysm clips or coils, skull metal plates, or implantable drug pumps; (2) Severe visual impairment, such as visual field loss or complete color blindness; (3) Upper limb dysfunction or pain due to shoulder subluxation, shoulder-hand syndrome, spinal cord injury, or peripheral nerve injury; (4) Concomitant other neurological diseases, such as Parkinson's disease and multiple sclerosis; (5) Severe cardiopulmonary disease or major organ dysfunction; (6) Unable to tolerate 30 minutes of fNIRS equipment; (7) Participation in other interventional trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Fugl-Meyer assessment for upper extremity;Instrumental Activities of Daily Living Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wolf Motor Function Test;Action Research Arm Test;Modified Ashworth Scale;task-related brain features based on fNIRS signals; | — |
Countries
China
Contacts
Public ContactShaofeng Zhao
The Eighth Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed