Diabetic Peripheral Neuropathy
Conditions
Interventions
Intervention group:Local injection of exosomes using a needle-free injector, administered twice per week for a duration of 2 months.
Control group:Local injection of normal saline using a needle-free injector, administered twice per week for a duration of 2 months.
Sponsors
Beijing Hospital, National Center of Gerontology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 Aged 18–70 years; 2 Diagnosed with type 2 diabetes mellitus; 3 Poor response to one or more medications for diabetic peripheral neuropathy, 4 A significant reduction in nerve conduction velocity (NCV); 5 HbA1c <= 9% within 3 months prior to enrollment.
Exclusion criteria
Exclusion criteria: 1 Presence of hemorrhagic disorders; 2 Use of anticoagulant medications; 3 Severe skin lesions at the injection site; 4 Participation in other clinical trials; 5 Use of medications affecting nervous system function within the past 3 months; 6 History of severe hepatic or renal insufficiency, cardiovascular disease, or other systemic diseases; 7 Previous exposure to radiotherapy or chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nerve Conduction Velocity (NCV); | — |
Countries
China
Contacts
Public ContactQi Pan
Beijing Hospital, National Center of Gerontology
Outcome results
None listed