spinal cord injury
Conditions
Interventions
Part 1: Spinal cord injury patient group:None
the experimental group:10Hz rTMS intervention in bilateral PMC and SMA regions
the control group:Perform rTMS intervention with a frequency of 10Hz in both M1 regions
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.The inclusion criteria of healthy subjects were as follows: 45-60 years old (age range matched with spinal cord injury group), both sexes; No neurological, musculoskeletal, psychiatric, or serious cardiovascular disease; Normal cognitive function (MMSE >=24-26); They voluntarily participated in the study and signed an informed consent form. 2.Inclusion criteria for patients with spinal cord injury: incomplete spinal cord injury (ASIA grade C or D), with certain sensory or motor function below the injury level; Onset time >=3 months; Age 45-60 years old, both sexes; Their cognitive function was normal (MMSE >=24-26), and they could understand and complete task-state experiments. The vital signs were stable, and there was no progressive nervous system disease or other serious diseases. They voluntarily participated in the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for healthy subjects: previous history of stroke, Parkinson's disease and other neurological diseases; Inability to cooperate with the experiment due to severe mental illness, epilepsy or family history of epilepsy or cognitive impairment; Having an implantable metal device or electronic device (such as a pacemaker); "Medications that may affect neurological function (e.g., antipsychotics, sedatives, antidepressants) were taken during the experiment."; 2.Exclusion criteria for stroke patients: diagnosis of complete spinal cord injury (ASIA grade A or B) (loss of CST function, rTMS may be ineffective); Acute or subacute spinal cord injury; Previous severe neurological diseases, such as stroke, Parkinson's disease; Equipped with implantable medical devices such as pacemakers; Severe cognitive impairment, psychiatric illness, or severe dystonia (such as overt spasticity); Severe lower limb spasticity or joint contracture, which affected the performance of experimental tasks; Recent neuromodulation therapy (such as spinal cord stimulation) may affect brain network function tests. They have cognitive impairment or serious psychological problems that affect experimental matching; Prior treatment with rTMS; Other conditions unsuitable for study participation, such as severe pain, infection, or postoperative recovery periods.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| American Spinal Injury Association injury classification (ASIA score) motor function score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting state fNIRS;Integral electrical values;Root mean square value;Instrumented balance assessment (stabilometry);Spinal Cord Independence Measure III (0–100);Modified Ashworth Scale for spasticity;Plantar pressure platform (eyes open/closed);Fugl-Meyer Assessment—Lower Extremity (0–34);MS-evoked motor potentials (latency, amplitude; CMCT if applicable);ask-based fNIRS: ß-values and functional connectivity (M1, SMA, PMC, S1, DLPFC);ISNCSCI neurological classification (NLI & AIS grade);10-Meter Walk Test (speed, m/s);Perceived walking exertion (Borg CR10);Lower Extremity Motor Score (LEMS);SCIM (generic version);Walking Index for Spinal Cord Injury II (0–20);Modified Barthel Index (0–100); | — |
Countries
China
Contacts
Public ContactChen Hemu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed