Helicobacter pylori infection
Conditions
Interventions
Experimental Group :Based on the antimicrobial susceptibility testing report, a personalized bismuth-containing quadruple therapy (PPI + Bismuth + two susceptible antibiotics) will be prescribed.
Control group :Empirical bismuth-based quadruple regimen (PPI + Bismuth + 2 antibiotics) will be initiated according to standard treatment guidelines and clinical judgment.
Observation group:None
Sponsors
The People's Hospital of Tongliao
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Part One, Epidemiological Investigation: The study subjects for this part will be the permanent resident population of the Tongliao region. 2. Part Two, Prospective, Randomized Controlled Trial: The inclusion criteria are: 1) Treatment-naïve patients with H. pylori infection, aged 18-80 years; 2) Those who provide informed consent and can tolerate the procedures involved in this study, including the string test, 13C-urea breath test, and the prescribed therapeutic regimen.
Exclusion criteria
Exclusion criteria: Part Two, Prospective, Randomized Controlled Trial: 1 Patients with severe cardiac, hepatic, or renal dysfunction, or psychiatric disorders; 2 Treatment-naïve patients who have taken antibiotics, proton pump inhibitors (PPIs), or related drugs within one month prior to enrollment; 3 Patients deemed ineligible to participate by the investigator's judgment; 4 Patients with a history of prior H. pylori eradication therapy or gastric surgery; 5 Patients with dysphagia who are unable to successfully swallow the string test capsule. Dysphagia will be rated using the Stooler scale: Grade 0 is eligible for enrollment; Grade 1 may be eligible after assessment; Grades 2, 3, and 4 will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H. pylori eradiction rate;Consistency between string test-qPCR and 13C urea breath test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hp infection rate and epidemiological characteristics; | — |
Countries
China
Contacts
Public ContactHuifang Pang
The People's Hospital of Tongliao
Outcome results
None listed