acute respiratory infection
Conditions
Interventions
Experimental group:Budesonide inhalation therapy
Placebo group:Placebo inhalation therapy
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 69 years old. 2. Have a history of coughing for more than 3 weeks after a previous acute respiratory infection. 3. Within 1 week of an acute respiratory tract infection, and have persistent cough symptoms (had one continuous cough episode lasting more than 1 hour within 24 hours, or had 3 coughing episodes within 24 hours). 4. Cough symptom severity score on the Visual Analogue Scale (VAS) = 4 points. Meet all of 1, 2, 3, and 4 simultaneously.
Exclusion criteria
Exclusion criteria: 1. Patients with mental illness, dementia, or those whom the researcher deems unable to accurately describe their symptoms. 2. Patients with known definite causes (including asthma or chronic obstructive pulmonary disease, etc.) leading to persistent airway symptoms. 3. Patients with structural lung diseases such as bronchiectasis or interstitial lung disease. 4. Patients with newly emerged patchy infiltrates, lobar/segmental consolidation, ground-glass opacities or interstitial changes on chest imaging, with or without pleural effusion. 5. Patients who have used inhaled or systemic corticosteroids within the past four weeks. 6. Patients allergic to budesonide or with contraindications to study-related drugs. 7. Pregnant and lactating women. 8. Patients who refuse to participate in this study. 9. Patients with severe underlying diseases: including malignant tumors, heart failure, liver or kidney insufficiency. 10. Patients whom the researcher deems unsuitable for inclusion due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of coughing at the 8th week after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of the cough;Improvement rate of cough symptom score;Improvement rate of quality of life score;Frequency of seeking medical treatment for coughing;The proportion of patients still using cough suppressants at the 8th week after treatment; | — |
Countries
China
Contacts
Public ContactSu Xin
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed