Maintenance peritoneal dialysis with malnutrition in end-stage renal disease.
Conditions
Interventions
Amino acid peritoneal dialysis solution group:None
Sponsors
The People's Hospital gaozhou
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Urinary patients with malnutrition during the screening period should undergo maintenance peritoneal dialysis for at least 3 months. The criteria for malnutrition must meet at least two of the following criteria: (1) serum albumin level7 points; 2.Blood urea nitrogen <= 38mmol/L; 3.The patient's age is between 18 and 75 years old; 4.Patient signs informed consent form;
Exclusion criteria
Exclusion criteria: 1.Individuals who are allergic to any amino acids or excipients in this product; 2.More than one occurrence of peritonitis within the past three months; Peritonitis or hospitalization within the past month; 3.Merge hyperthyroidism, systemic infections, fever, and other high catabolic metabolic diseases, as well as taking drugs that affect tissue metabolism, such as corticosteroids; 4.Congenital amino acid metabolism deficiency disease, acute severe pancreatitis, severe hyperbilirubinemia; 5.Individuals with malignant tumor metastasis or spread, residual cancer lesions after treatment, coagulation dysfunction, aplastic anemia, and other serious systemic diseases such as heart, brain, and lung; 6.Possible kidney transplant during the trial period; 7.Hepatitis B or active hepatitis C, cirrhosis, active liver disease, liver dysfunction, or positive serum reaction for human immunodeficiency virus (HIV); 8.Individuals who have participated in clinical trials of other drugs within the three months prior to enrollment; 9.Pregnant and lactating women; 10.Mentally unable to cooperate; 11.Unsigned written informed consent form; 12.Unable or unwilling to comply with the experimental protocol recognized by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Albumin;prealbumin; | — |
Secondary
| Measure | Time frame |
|---|---|
| weight;body mass index;conicity index;waist circumference;Upper arm muscle circumference;Normalized protein catabolic rate;Normalized protein nitrogen appearance;glycosylated hemoglobin;Fasting blood glucose;Urine output;Peritoneal dialysis ultrafiltration volume;Kt/V;Ccr;peritoneal equilibration test; | — |
Countries
China
Contacts
Public ContactShanshan Deng
The People's Hospital gaozhou
Outcome results
None listed