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Establishment of an AI model for the diagnosis of heart failure based on chest CT imaging

Establishment of an AI model for the diagnosis of heart failure based on chest CT imaging

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108759
Enrollment
Unknown
Registered
2025-09-04
Start date
2025-09-05
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

Gold Standard:The gold standard of this study is defined as echocardiographic evidence of left ventricular ejection fraction (LVEF) 450 ng/L for patients younger than 50 years, > 900 ng/L for those a
Index test:Chest CT imaging

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: *Heart Failure Patients I. Meet the diagnostic criteria for heart failure (based on the *Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024* \[3]); II. Aged 18–80 years, regardless of sex; III. NYHA functional class II to IV; IV. Left ventricular ejection fraction (LVEF) < 50%; V. Have received at least 2 weeks of standardized heart failure medication treatment. *Healthy Controls I. Aged 18–80 years, regardless of sex.

Exclusion criteria

Exclusion criteria: *Heart Failure Patients (Exclusion Criteria) I. Heart failure caused by congenital heart disease, acute heart failure, or heart failure following acute myocardial infarction; II. Planned to undergo coronary revascularization or cardiac resynchronization therapy within 8 weeks; III. Patients with myocarditis, aneurysm, left ventricular outflow tract obstruction, or unrepaired valvular heart disease causing significant hemodynamic changes; IV. Patients with cardiogenic shock, uncontrolled malignant arrhythmias, second-degree type II or higher sinoatrial or atrioventricular conduction block without pacemaker implantation, progressively worsening unstable angina, or acute myocardial infarction; V. Patients with concomitant pulmonary infection, malignancy, psychiatric disorders, or severe hematologic, neurologic, or endocrine diseases; VI. Patients with severe primary liver or kidney disease, or severely impaired hepatic or renal function; VII. Patients with uncontrolled hypertension (systolic BP =180 mmHg and/or diastolic BP =110 mmHg); VIII. Participation in other drug clinical trials within the past month; IX. Pregnant or lactating women, or those planning to become pregnant. *Healthy Controls (Exclusion Criterion) I. History of heart failure.

Design outcomes

Primary

MeasureTime frame
Chest CT imaging;—

Countries

China

Contacts

Public ContactJunbo Ge

Zhongshan Hospital, Fudan University

junbge@hotmail.com+86 21 6404 1990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026