None
Conditions
Interventions
Group 1:White rice - Brown rice - Glucose
Group 2:White rice - Glucose - Brown rice
Group 3:Brown rice - White rice - Glucose
Group 4:Brown rice - Glucose - White rice
Group 5:Glucose - White rice - Brown rice
Group 6:Glucose - Brown rice - White rice
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-45 years (inclusive); 2.Both genders eligible; 3.Individuals with normal digestive function (i.e., non-dyspeptic) or those with postprandial distress syndrome (planned recruitment: 15 participants with normal digestive function and 15 with postprandial distress syndrome); 4.Normal glycemic status or prediabetes; 5.Voluntary participation with signed informed consent; 6.Ability to perform light physical activities in the morning and maintain predominantly sedentary behavior during the 14-day period, with no physical education classes; 7.Habitual breakfast consumers willing to accept white rice, brown rice, and glucose solution as test meals; 8.Commitment to maintain regular sleep patterns (before 12:00 AM) without night-time sleep deprivation during the trial.
Exclusion criteria
Exclusion criteria: 1.Pregnancy, lactation, or diagnosis of major systemic diseases (including malignancies and severe psychiatric disorders). Strict exclusion of organic gastrointestinal pathologies including but not limited to: gastric cancer, colorectal cancer, gastroesophageal reflux disease, esophagitis, esophageal carcinoma, peptic ulcers, Crohn's disease, intestinal obstruction, inflammatory bowel disease, hepatitis, cirrhosis, hepatocellular carcinoma, cholelithiasis, cholecystitis, cholangitis, cholangiocarcinoma, pancreatitis, pancreatic cancer, peritonitis, and abdominal hernias. 2.History of diabetes mellitus or known genetic syndromes/diseases affecting glucose tolerance (e.g., glucose-6-phosphate dehydrogenase deficiency, polycystic ovary syndrome). 3.Use of medications known to interfere with glucose tolerance within the preceding month (including thiazide diuretics, corticosteroids, spironolactone). 4.Administration of medications affecting appetite or gastrointestinal function within the past 30 days. 5.Recent (within 1 month) use of antibiotics or probiotics. 6.Active participation in weight loss programs. 7.Tobacco smoking or chronic alcohol abuse. 8.Inability to operate smartphones or unwillingness to wear continuous glucose monitoring devices. 9.Concurrent enrollment in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial glucose area under the curve;Peak postprandial blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to peak blood glucose;Time to return to fasting blood glucose level;Number of blood glucose peaks;Maximum blood glucose excursion;Glycemic index;Glycemic load; | — |
Countries
China
Contacts
Public ContactRuixin Zhu
China Agricultural University
Outcome results
None listed