Acute pancreatitis
Conditions
Interventions
Intervention group:Ultra-early preventive fluid resuscitation cluster treatment plan for acute pancreatitis
Control group:Conventional treatment protocol (non-cluster treatment protocol)
Sponsors
Rongxian People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who meet the clinical diagnosis of the Guidelines for Diagnosis and Treatment of Acute Pancreatitis in China (Shenyang, 2019) and are diagnosed with mild acute pancreatitis (MAP) or moderately severe acute pancreatitis (MSAP); 2. Onset time = 18 years old; 3. No fluid resuscitation was performed before admission (pre-hospital and out-of-hospital infusion volume < 500ml/24h).
Exclusion criteria
Exclusion criteria: 1. Patients with confirmed or suspected malignant tumor; 2. Patients with immunosuppression had used or were using immunosuppressants within 30 days, or had used glucocorticoids for more than 3 weeks within 60 days, or had white blood cells less than 0.5 × 10^9/L, or platelets less than 25 × 10^9/L; 3. Patients had severe comorbidities that might affect the outcome or safety of the study, including anemia (hemoglobin < 90 G/L), chronic renal insufficiency (EGFR < 60 ml/min/1.73 m ²), liver cirrhosis, severe chronic lung disease (e.g., GOLD stage III or IV chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, bronchiectasis, or cystic fibrosis, etc.), severe cardiovascular disease (e. NYHA class ? or ? heart failure, acute coronary syndrome, severe valvular disease within 3 months); 4. Pregnant or lactating women; 5. Refuse to be enrolled or give up treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SAP incidence;28-day case fatality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complication rate;Cost of treatment;Incidence of fluid overload;Incidence of requiring invasive mechanical ventilation;Incidence of requiring blood purification therapy;Total hospitalization days; | — |
Countries
China
Contacts
Public ContactYu Wang
Rongxian People's Hospital
Outcome results
None listed