Major depressive disorder
Conditions
Interventions
Intervention group:Creatine monohydrate
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meets DSM-5 diagnostic criteria for a depressive disorder, without psychotic features; 2.Chinese residents aged 18–65 years, of either sex; 3.Educational attainment of at least primary school; 4.Has been on a stable, single antidepressant regimen for >= 2 weeks; 5.Voluntarily participates and provides written informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe physical illnesses (e.g., cardiac or renal insufficiency, epilepsy, endocrine disorders); 2.Comorbid psychiatric disorders (e.g., bipolar disorder, schizophrenia, substance dependence); 3.Previous or current use of creatine or other related nutritional supplements; 4.Abnormal renal function (serum creatinine or blood urea nitrogen outside the normal range); 5.Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression severity;Electroencephalogram indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cultural composition;Creatine and its metabolites (creatinine, creatine kinase);Demographic data;Course;Anxious;Electrolyte;Renal function;Mania;Temporal Pleasure Experience ;SHAPS;Waist-to-hip ratio;EIS;BMI;Hamilton Depression ;PHQ-9;Family history; | — |
Countries
China
Contacts
Public ContactJiamin Han
Wuxi Mental Health Center
Outcome results
None listed