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Observation of Preventing Postoperative Pharyngeal Complications by Administering Dexamethasone via Different Routes in Combination with Lidocaine, a randomized double-blind controlled trial

Clinical observation of Preventing Postoperative Pharyngeal Complications by Administering Dexamethasone via Different Routes in Combination with Lidocaine

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108716
Enrollment
Unknown
Registered
2025-09-03
Start date
2025-10-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pharyngeal complications after general anesthesia

Interventions

Intravenous dexamethasone group:Intravenous injection of dexamethasone at 0.1mg/kg
Lidocaine spray combined with intravenous dexamethasone group:Dexamethasone at a dose of 0.1mg/kg was intravenously injected, and 3ml of 2% lidocaine was sprayed on the throat during anesthesia induct
Lidocaine combined with dexamethasone local spraying group:Spray 3ml of 2% lidocaine combined with 0.1mg/kg dexamethasone on the throat and subglottic region

Sponsors

Anqing Municipal Hospital, Anhui Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: (1) Laparoscopic hernia repair surgery is planned to be performed; (2) ASA classification I-III; (3) The patient's age is =18 years old and <65 years old. (4) BMI index: 18-30 kg/m ²; (5) Ethical compliance, patients voluntarily accepted this trial and signed the informed consent form

Exclusion criteria

Exclusion criteria: (1) Severe dysfunction of the heart, lungs, liver or kidneys; (2) Have a history of mental illness or long-term psychotropic drugs (dementia, schizophrenia); (3) Those who are contraindicated to the use of glucocorticoids; (4) Those who have language communication impairments, hearing impairments or brain function disorders such as stroke and are unable to communicate; (5) Those who are not suitable for endotracheal general anesthesia as assessed before the operation, or those whose glottis cannot be peeked through during induction and thus cannot be subjected to surface anesthesia; (6) Participated in other drug clinical studies within the past 30 days

Design outcomes

Primary

MeasureTime frame
Postoperative Pharyngeal Complications(postoperative sore throat,Postoperative hoarseness,throat dry,throat itchy);

Secondary

MeasureTime frame
Preoperative and postoperative blood glucose levels;The incidence of choking cough during extubation;Operation time, anesthesia time;Incidence of postoperative adverse reactions(Nausea and vomiting, incision infection, delayed healing, etc);Patient satisfaction with anesthesia;

Countries

China

Contacts

Public ContactXu Huang

Anqing Municipal Hospital, Anhui Province

393864473@qq.com+86 158 5657 5382

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026