Atrophic acne scars or atrophic scars caused by trauma/surgery
Conditions
Interventions
Control Group:Punch Surgery + Autologous Nanofat Grafting
Study Group:Punch Surgery + CEFFE Matrix Grafting
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with severe facial atrophic acne scars or linear atrophic scars caused by trauma/surgery; 2.Acne or trauma has fully healed, with stable atrophic scars for more than 6 months; 3.Age: 18–60 years (inclusive), male or female; 4.Voluntary participation with signed informed consent and ability to comply with 6 months of treatment and follow-up; 5.No prior treatment for atrophic scars within the last 3 months; 6.Willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with allergy to lidocaine; 2.Women who are planning pregnancy, currently pregnant, or breastfeeding; 3.Patients with history of psychiatric disorders, severe psychological conditions, or major organ diseases that may interfere with long-term follow-up; 4.Patients with allergic predisposition or a family history of keloid/hypertrophic scar formation; 5.Patients with history of malignant tumors; 6.Patients with hematologic or immune system diseases that contraindicate surgery; 7.Patients with active facial infections, inflammation, herpes, psoriasis, or other autoimmune diseases, or those undergoing immunotherapy; 8.Patients who have participated in any other clinical trials within the past 3 months; 9.Other conditions deemed ineligible by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laboratory indicators;Overall Response Rate;Vital Signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| VISIA Quantitative;Scales Score;3D Scanning Assessment and Quantitative ;Scar texture; | — |
Countries
China
Contacts
Public ContactWei Liu
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed