Acute lung injury
Conditions
Interventions
Non-Acute lung injury group:None
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective extracorporeal circulation-assisted cardiovascular surgery; 2.age >=18 years; 3.ASA (American Society of Anesthesiologists) classification ?-?; 4.estimated operative time >=2 hours;
Exclusion criteria
Exclusion criteria: 1.Preoperative infections or severe lung diseases (e.g., lung infection, pulmonary atelectasis, emphysema, pulmonary heart disease, pleurisy, etc.); 2.history of acute lung injury or acute respiratory distress syndrome in the last 3 months prior to the operation; 3.pregnant or breastfeeding females; 4.BMI (Body Mass Index) > 40 kg/m^2; 5.functional or organic diseases of the intestinal system (e.g., irritable bowel syndrome, ulcerative colitis, etc.), or have taken antibiotic preparations for more than 7 consecutive days in the last 3 months; 6.have participated in other clinical trials in the last 3 months; 7.the presence of other significant comorbidities, such as acute myocardial infarction, chronic renal failure, and other serious systemic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;Minimum PaO2/FiO2 at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay, postoperative mechanical ventilation, length of hospital stay; | — |
Countries
China
Contacts
Public ContactHei Feilong
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed