Chronic rhinosinusitis
Conditions
Interventions
Test group:Patients in the experimental group will undergo functional endoscopic sinus surgery using a novel suction bipolar electrocautery device for intraoperative hemostasis.
Control group:Patients in the control group will undergo functional endoscopic sinus surgery using a suction monopolar electrocautery for intraoperative hemostasis.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 75 years; (2) Diagnosed with chronic rhinosinusitis (CRS), with or without nasal polyps, in accordance with the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020); (3) Scheduled for primary functional endoscopic sinus surgery (FESS); (4) Preoperative Lund-Mackay score >=5 on sinus CT; (5) Normal coagulation function (platelet count, PT, and APTT within reference ranges or clinically acceptable); (6) Provided written informed consent after fully understanding the study protocol; (7) No participation in other clinical trials within the past three months.
Exclusion criteria
Exclusion criteria: (1) known contraindications to general anesthesia or nasal endoscopic surgery; (2) long-term use of anticoagulants or other medications affecting coagulation; (3) long-term systemic corticosteroid therapy; (4) major systemic diseases, including immunodeficiency (e.g., HIV infection or long-term immunosuppressant use), uncontrolled hypertension (>=160/100 mmHg despite >=3 medications), uncontrolled diabetes (HbA1c > 9%), or active pulmonary tuberculosis; (5) nasal drug-eluting stent placement within the past 3 months; (6) prior nasal surgeries (e.g., septoplasty, sinus surgery, turbinate surgery); (7) pregnancy, lactation, or other physiological conditions likely to affect outcomes; (8) pre-existing ocular structural diseases (e.g., glaucoma, optic atrophy, high refractive error) or history of eye surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sinonasal ventilation status: Lund-Kennedy score;Symptom improvement: Sino-Nasal Outcome Test-20 (SNOT-20); | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrence rate of nasal polyps;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLiu Feng
West China Hospital, Sichuan University
Outcome results
None listed