Schizophrenia
Conditions
Interventions
Patient group:None
Healthy control:None
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patient Group: 1.Participants must meet the diagnostic criteria for "Schizophrenia" or "Schizoaffective Disorder" as defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). The diagnosis for each patient must be independently confirmed by at least two attending psychiatrists or psychiatrists of a higher professional rank. 2.Aged between 18 and 65 years. 3.No prior history of systematic antipsychotic medication treatment, and no use of any antipsychotic medication for at least two weeks prior to enrollment in this study. 4.A total score of >=60 on the Positive and Negative Syndrome Scale (PANSS). 5.Capable of cooperating to complete the cognitive function assessment (MATRICS Consensus Cognitive Battery, MCCB). 6.The patient or their legal guardian must agree to participate in this study and provide written informed consent. Healthy Control Group: 1.Healthy individuals matched with the patient group for key demographic variables such as gender and age. 2.No history of psychiatric disorders or cognitive impairment. 3.Willing to participate in this study and provide written informed consent. Healthy subjects for this study will be recruited from the community.
Exclusion criteria
Exclusion criteria: 1.Individuals who meet the DSM-5 diagnostic criteria for any mental disorder other than "Schizophrenia" or "Schizophreniform Disorder." 2.Individuals with co-occurring severe physical diseases (e.g., autoimmune diseases, metabolic syndrome) or brain organic diseases. 3.Individuals with a history of alcohol abuse or use of other psychoactive substances. 4.Women who are pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Metabolites level; | — |
Countries
China
Contacts
Public ContactYeqing Dong
Tianjin Anding Hospital
Outcome results
None listed